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Aim and Background: Mental health is one of the vital factors in human life. Even, the mental health is important in improving the diseases of the patients. The aim of this study was to investigate the intermediate role of resilience mediation in the relationship between the meaning of life and spiritual health with mental health in patients with colon cancer. Methods and Materials: Participants were 120 patients with colon cancer in stages 1 or 2 selected via convenience sampling method. Participants completed the Meaning in Life Scale (MiLS), Paloutzian and Ellison Spiritual Well-Being Scale (SWBS), Conner-Davidson Resilience Scale Mils Scale (CD-RISC), and Symptom Checklist-25 (SCL-25) questionnaire. Findings: Meaning of life and spiritual health were not able to predict mental health; but, resiliency could predict mental health in a positive and meaningful way. Values, goals, and life perspective components of meaning of life could tend to more resiliency, and result in more mental health. In addition, there were positive significant relationship between the meaning of life, spiritual health, and resilience mediation with mental health. Conclusions: The results showed that values, goals, and life perspective components of the meaning of life can increase the resilience, and thus reduce mental disorders and increase mental health.

Keywords: Spirituality, Resiliency, Mental health, Colon cancer

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