Volume 13, Issue 1 (12-2015)
RBS 2015, 13(1): 100-113 |
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موسوي س م, کمالي ا, کريمي پ, صالحي م, کاراحمدي م. From the Maternal Prenatal Stress to Risk of Autism: The Severity and Timing of the Stressors at the Epicenter. RBS 2015; 13 (1) :100-113
URL: http://rbs.mui.ac.ir/article-1-390-en.html
URL: http://rbs.mui.ac.ir/article-1-390-en.html
1- دانشجوي دکترا، بخش ژنتيک، گروه زيست‌شناسي، دانشكده‌ي علوم، دانشگاه اصفهان، اصفهان، ايران
2- دانشجوي دکترا، بخش ژنتيک، دانشکده‌ي علوم زيستي، دانشگاه تربيت مدرس، تهران، ايران
3- دانشيار، گروه ژنتيک و بيولوژي مولکولي، دانشکده‌ي پزشکي، دانشگاه علوم پزشکي اصفهان، مرکز ژنتيک پزشکي ژنوم، خيابان شريعتي، اصفهان، ايران
4- دانشيار، مرکز تحقيقات علوم رفتاري، بيمارستان نور و حضرت علي اصغر، گروه روان‌پزشکي، دانشکده پزشکي، دانشگاه علوم پزشکي اصفهان، اصفهان، ايران
2- دانشجوي دکترا، بخش ژنتيک، دانشکده‌ي علوم زيستي، دانشگاه تربيت مدرس، تهران، ايران
3- دانشيار، گروه ژنتيک و بيولوژي مولکولي، دانشکده‌ي پزشکي، دانشگاه علوم پزشکي اصفهان، مرکز ژنتيک پزشکي ژنوم، خيابان شريعتي، اصفهان، ايران
4- دانشيار، مرکز تحقيقات علوم رفتاري، بيمارستان نور و حضرت علي اصغر، گروه روان‌پزشکي، دانشکده پزشکي، دانشگاه علوم پزشکي اصفهان، اصفهان، ايران
Abstract: (2027 Views)
Abstract Aim and Background: Recent studies on autism, as the most important diseases in the autism spectrum disorders, emphasize the slight role of genome in causing autism compared to earlier estimates, and the leading role of environmental factors such as prenatal maternal stress in developing autism, mainly due to its high potential of perverting the neurodevelopment of embryo. Methods and Materials: In order to assess this hypothesis in Iran, some mothers of autistic children were compared with mothers of healthy children in terms of quantity, quality and timing of exposure to 45 stressful events in a 15-month period (6 months before pregnancy to the moment of birth). In addition, dividing these stressful events into two groups of genome-dependent events) events resulting from gene-environment interactions such as divorce and addiction) and genome-independent events (purely environmental events such as war and earthquake), their prevalence was separately scrutinized and compared among patient and control families. Findings: According to the results of this study, the severity and frequency of exposure to stress among mothers of autistic children were significantly greater than that of control mothers (p=0.000). Although the child’s risk of autism increases significantly with the increase of maternal stress during 4-7 months (14-32 weeks) of pregnancy, the results of this study showed that the increased maternal stress during 2-3 months (5-13 weeks) of pregnancy leads to a significant increase in the severity of autism (p<0.05). Conclusions: However, although the present study consistent with recent findings in the fields of epigenetics and gene-environment interactions can reinforce the possible role of severe and scheduled prenatal stresses in autism, it does not deny the necessity of a prospective and wider study in Iran.
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