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Aim and Background: Numerousfactorsincludingsocial, economicandpsychologicalstresseshave a role inthegroundsand incidenceof addiction.The purpose of this study was to investigate the effectiveness of cognitive-behavioral stress managementon promotion ofdifferent domains ofquality oflife in men who are substance dependent. Methods and Materials: In an experimental study, 30 individuals who settled in Isfahan Therapeutic Community Center, Iran, were randomlydivided into experimental (15 subjects) and control (15 subjects) groups. The experimental group underwent ten 90-minute sessions of cognitive-behavioral stress management and the control group did not receive any particular treatment. All participants completed the quality of life inventory (SF-36) at the beginning of the study, completion of treatment and three months following the completion of treatment. Findings: Analysis of covariance results showed a significant difference between the two groups in promotion of different domains ofquality of life including physical function (F=4.09, P=0.012),physical role limitations (F=3.56, P=0.021), body pain(F=4.77, P=0.006), general health(F=3.98, P=0.014), vitality(F=9.36, P<0.0001), social function(F=17.57, P<0.0001) and mental health(F=5.42, P= 0.004)in the post test stage.In addition, analysis of covariance with repeated measuresshowed a significant difference in body­ pain(F=7.04, P = 0.013), general health(F=7.05, P= 0.013)in thefollow-up stages. Conclusions: Cognitive-behavioral stress management is effective in promotion of different domains ofquality of life in men who are substance dependent.

Keywords: Stress management, Quality of life, Substance dependence

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