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Aim and Background: The aim of this study was to compare the efficacy of cognitive-behavioral therapy (CBT) and acceptance and commitment therapy (ACT) in reducing depression symptoms in patients with multiple sclerosis (MS). Methods and Materials: This experimental study was conducted with pretest-posttest design and control group. From among female patients with MS who referred to the MS Society in 2015 with depression symptoms, a sample of 45 individuals was selected. The subjects were randomly divided into 3 groups of CBT, ACT, and control (n = 15). Therapy sessions consisted of 8 sessions, each session was held for 45 minutes. Data were collected using the Beck Depression Inventory (BDI) and were analyzed using ANCOVA in SPSS software. Findings: The results showed that CBT and ACT were both effective in reducing depression symptoms in patients with MS (P < 0.001), but CBT was more effective compared to ACT. Conclusions: The results showed that CBT and ACT are effective methods of reducing depression in patients with MS. Due to the higher efficacy of CBT, it has been suggested as the preferential treatment for the reduction of depression symptoms in patients with MS.

Keywords: Cognitive behavioral therapy, Acceptance and commitment therapy, Multiple sclerosis, Depression

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