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Aim and Background: Depression is the prevalent disease of the present era and has a high prevalence in teenagers. Depression is observed in all age groups and races, and both in women and men. Depression includes clinical disorders, mood disorders, and emotional disorders, and causes mental confusion, emotional distress, behavioral disorders, and even physical ailments in adolescents. It renders adolescents vulnerable to anxiety disorders and other mood disorders. Moreover, comorbidity among depression, attention-deficit/hyperactivity disorder (ADHD), and drug dependence is common. The aim of the present research was to study comorbidity of disorders and depression in adolescents. Methods and Materials: This was a descriptive study. The statistical population consisted of 1606 students of 11 to 16 years of age from boys and girls junior guidance schools (public and private) of the five educational districts of Isfahan, Iran, in the year 2008-2009. The participants were selected through random cluster sampling; 303 students with depression and 303 students without depression. For both groups of students, Kiddie-SADs questionnaire was completed. To compare the prevalence of comorbid disorders among students with and without depression, chi-square test was used. Findings: In this study, the frequency of separation anxiety disorder (SAD), generalized anxiety disorder (GAD), obsessive-compulsive disorder (OCD), social anxiety disorder, agoraphobia, attention deficit hyperactivity disorder (ADHD), conduct disorder (CD), oppositional defiant disorder (ODD), and manic depression, among was significantly higher among students with depression (P < 0.005) than students without depression. Fisher&#039;s exact test showed that the frequency of substance use disorder (SUD) and post-traumatic stress disorder (PTSD) among students with and without depression was not significantly different. Conclusions: This study showed that, with the exception of SUD and PTSD, the frequency of comorbid disorders in students with depression was significantly higher than students without. In other words, there is a relationship between depression and the studied comorbid disorders.

Keywords: Comorbid disorders, Depression, Students

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