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Abstract Aim and Background: Based on the reinforcement sensitivity theory, normal and abnormal personalities are located along with a continuum. The aim of this study is comparing the behavioral inhibition systems and activation systems on different drug users, heroin withdrawers with normal persons. Methods and Materials: The present research applied fragmentary descriptive method and the statistical population was consisted of all drug-users who were under maintaining treatment with methadone, shisha- users, heroin-users, opium-users and heroin-withdrawers in Isfahan City in 2013, so that 150 users of different drugs and 30 men who did not use anything were selected and tested by the cluster sampling and the Gary Wilson&rsquo;s personality questionnaire (QWPQ). Findings: The results of variation analysis showed that there is a significant difference among the groups from the point of view of the behavioral activation level (P<0.05). No meaningful difference has obtained between the groups from the point of view of behavioral inhibition system and escape-fight system (p<0.05). The results of Post-Hoc Test represented that the mean behavioral activation&nbsp; in heroin user group is meaningfully more than normal groups, heroin and opium withdrawers and methadone users (p<0.05). Also the mean behavioral activation in shisha-users is meaningfully more than opium withdrawers and methadone users (p<0.05).There was no meaningful difference between other groups. Conclusions: This study is supported a hypothesis that represented drug-users enjoy thehyper function in activating-behavior system.

Keywords: Activation, Inhibition, Addiction

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