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Abstract Aim and Background: The research purpose is to assess the Efficacy of Emotion Regulation on the Well-Being of Epileptic Girls (14-20) in Isfahan. Methods and Materials: In order to administer this study, 30 epileptic adolescence girls were selected from 14-20 years population of epileptic adolescence girls Isfahan city in 2012 via sampling available method and assigned randomly to experimental and control group (each group consist of 15 adolescence). The intervention was emotion regulation . Training based on Boston Program University. The instruments were psychological Well-Being (Ryff) Questionnaire And the Researcher-Made Questionnaire . Findings: Data was analyzed by Multivariate Covariance analysis of variance. Findings indicate that emotional regulation effects on the Well-Being of epileptic girls in pre and post test and follow-up (P<0 . 019). Also mean scores of Self Acceptance(P<0 . 049) in the post test was significantly higher in the experimental group than in the control group. The results also showed that the mean scores of positive relations with others (P<0 . 045), Self- Acceptance (P<0 . 049), purpose in life (p<0 . 046) in the follow - up was significantly higher in the experimental group than in the control group. Conclusions: The results showed that emotional regulation effects on the Well –Being of epileptic girls. The treatment effect was sustained during the follow-up

Keywords: Emotion Regulation, Cognitive-Behavioral, Psychological Well-Being

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