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Aim and Background: The present study aimed to determine the effectiveness of cognitive-behavioral stress management on reducing anxiety, stress, and depression symptoms in head-family women under the coverage of Imam Khomeini's Relief Committee. Methods and Materials: Forty subjects were selected using simple random sampling method and assigned into experimental and control groups. With a pre-test and post-test control group design, the subjects in the intervention group underwent 10 sessions of cognitive-behavioral stress management training, but the control group did not. Both groups were evaluated using depression, anxiety, and stress scale in two assessment phases, and data were analyzed by multivariate analysis of covariance (MANCOVA). Findings: Findings showed that there was no statistically significant difference between the two groups in pretest phase, but cognitive-behavioral stress management training, significantly decreased depression, anxiety, and stress scores in the experimental group. Conclusions: The cognitive behavioral stress management training could be an intervention program in target groups and general population under the coverage of Imam Khomeini's Relief Committee counseling centers, and with reducing depression, anxiety, and stress symptoms led to reduction in client’s problems and enhancing productivity.