Abstract Aim and Background: Multiple Sclerosis (MS) is a progressive disease and can extremely affect on body esteem at patients and changes obviously Emotions and attitudes with body in patients. Based on this study was to examine body esteem in patients with MS. Methods and Materials: This research Study was descriptive, 395 patients of the MS Society in Tehran in 2012 were selected by convenience sampling. Data gathering tool was a questionnaire of body esteem. Data was analyzed by independent t-test, ANOVA, Pearson correlation and post hoc Scheffe test using SPSS/16. Findings: According to score of body esteem (3.25) and the overall average score for body esteem (42.25), Patients with multiple sclerosis had favorable body esteem. There were significant relationship between body esteem and marital status (p=0.011), educational level (p<0.001), occupational status (p=0.004), income monthly (p<0.001) and duration of disease (p=0.004), whereas this relationship for between body esteem and age were significant inverse (p<0.001). Conclusions: Where of Human feeling about body esteem is equal to value that hears, sees and senses is created in the mind and community have a role effective in improvement body esteem, the nurses can change people reaction in the first encounter with physical disabilities and so play a main role in positive assessment body esteem and take up valuable of them.