Dr. Saeed Alvandian, Prof. Mojgan Karahmadi, Volume 22, Issue 2 (8-2024)
Abstract
Aim and Background: Oppositional defiant disorder is a negative, hostile behavior pattern combined with disobedience, and because this disorder can lead to family or academic problems in children, it is of great importance. This study was conducted with the aim of determining the effectiveness of adding Sarcosine to PMT behavioral therapy on the treatment of oppositional defiant disorder. Methods and Materials: In this clinical trial study, 80 children aged 6-12 with oppositional defiant disorder were randomly divided into two groups of 40 people. On the management treatment of parent education, the drug was prescribed at a dose of 0.03 grams per kilogram daily for 12 weeks. Before and after the intervention, all patients were assessed for the severity and frequency of the problem of neglect-confrontational behavior with the Eyberg(ECBI) questionnaire and the results of the two groups were compared. Findings: The mean score of the severity of the neglect-confrontational behavior according to the Eiberg questionnaire before and after the intervention in the Sarcosine group was 115.3 ± 25.5 and 103.5 ± 21.7, respectively, and the difference before and after the treatment was significant (P<0.001). In the placebo group, the mean score before and after the intervention was 113.7 ± 28.9 and 108.8 ± 25.7, respectively, and the difference between before and after was significant (P=0.035). Conclusions: The findings of the present study showed that the use of Sarcosine alone with parents education management therapy can lead to a more favorable effect and speed up the treatment of children with defiant-oppositional disorder.
