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Aim and Background: Patients with ischemic heart disease in acute stage experienced great anxiety and in compared with patients had less anxiety were affected 5 times more to ischemia, re-infarction, tachycardia, arrhythmias and ventricular fibrillation.  Excessive anxiety delays recovery and increases the probability of their death in the first month. Numerous studies have shown that heart disease affect the person's spirituality and suggested that interventions based spirituality may reduce anxiety. Thus, with regard to results of the research findings, vast library search, expert's opinion, one spirituality care program developed and considered its impact on anxiety of ischemic heart patients hospitalized in CCU. Methods and Materials: This was a randomized clinical trial. Sixty-four ischemic patients in CCU randomly divided into test and control groups. Spiritual care program included supportive presence, support from patient’s rituals, and using supportive systems for 3 days and Anxiety Questionnaire completed before and after the intervention for the both groups. Data analysis done through software SPSS and chi-square, independent-t and paired t-tests. Results: Mean score of Anxiety had no significant difference before intervention between two groups (P = 0.91); whereas paired t-test showed there was a significant difference in the test group before and after the intervention (P=0.001), also mean score of anxiety had a significant difference between test and control groups after the intervention (P=0.03). Conclusion: With regard to results of present study spirituality care program could reduce anxiety of ischemic heart patients hospitalized in CCU, so nurses could apply spirituality care program to decrease the anxiety of patients.