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Background& Aim: Substance abuse is associated with high prevalence of psychiatric disorders including mood disorders (especially depression), personality disorders and psychosis. The purpose of this study was to investigate the effect of methadone and its result on substance induced depression-symptoms among IV drug abusers of Kashan prison in 1384. Method & Materials: This is a semi-experimental study. A two part questionnaire including demographic data and Beck Depression Inventory (BDI) were administered to participants by the prison clinical psychologist. After insuring privacy, performing the questionnaire, and interviewing with each participant done by three psychologists, oral methadone was prescribed to non-excluded participants. After three months of taking methadone, they were re-evaluated by BDI and re- interviewed by psychologists for making diagnoses based on DSM-IV. Data were analyzed by paired T-test.   Findings: Based on clinical interview, from the 35 participants, 26(74.2%) were diagnosed as having Major Depressive Disorder , 2 of whom were excluded from the study and referred for further follow up because of suicidal thinking .The rest 9 participants (25.7%) were not depressed. After the intervention, of all 24, 19 ones(79.16%) showed relative improvement and 5(20.83%) remained unchanged. A significant reduction was found in the mean BDI score after the intervention(p Conclusion: This study showed that methadone can reduce depression severity in IV drug abusers.

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Aim and Background: Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system in which primary symptoms emerges in adults between the age 20 and 40 years old. Previous findings indicate 15-20 percent of Multiple Sclerosis (MS) patients are diagnosed with executive function impairments. The purpose of this study is to evaluate planning function as one of executive functions subsets in patients with relapsing-remitting MS.   Method and Materials: In this ex-post facto study which is done in Esfahan MS association, 49 female with relapsing-remitting MS and 43 female age-, education- and IQ-matched without MS were selected by haphazard sampling. To assess their planning function, both groups were tested using Tower of Hanoi task. Findings: Multivariate analysis of variance shows significant difference between to group in three, four, five, six and seven movement tasks(p<0/ 001). Additionally, patient group has more extra moves (errors) than observe, considering that there was no limitation in time. To measure the sensitivity and specificity of different tasks of Tower of Hanoi task, ROC curve is applied. All curves were located above the reference line. Conclusions: Findings indicate patients with MS had impairment in planning function which is not caused by deficit in their general IQ. Also results showed that six and seven movement tasks of the Tower of Hanoi have higher sensitivity and specificity for assessing planning function.

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 Aim and Background: Multiple sclerosis (MS) can significantly affect the quality of life and daily life activities of caregivers, and how to cope with stressful situations and challenges for caregivers is determined by the personality of the caregiver. Based on this, this research was conducted with the aim of investigating the role of low positive emotions, anxiety-related experiences and helplessness/hopelessness based on MMPI-3 in the experience of suffering and caregiver burden of caregivers of patients with multiple sclerosis.
Methods and Materials:  The current research method was fundamental, cross-sectional, and descriptive of the correlation type. The statistical population included all the caregivers of MS patients in Mashhad city, who had visited specialized neurology clinics and Mashhad MS patients' support association between October and December 2024, and 336 of them were selected by convenience sampling method. The research tools included the Minnesota multidimensional personality questionnaire - third edition, caregiver burden scale, and suffering assessment questionnaire. For data analysis, multiple regression analysis were used in SPSS version 26 statistical software. 
Findings: The results of the present study showed that the highest correlation was observed between anxiety-related experiences and the Experience of Suffering and the lowest correlation was observed between anxiety-related experiences and the helplessness/hopelessness. Also, helplessness/hopelessness and anxiety-related experiences explain 23% of the variance of suffering experience. In addition, it was found that experiences related to anxiety, low positive emotions, and helplessness/hopelessness explained 41% of the variance of caregiver burden.
Conclusions: Based on this and considering the relationship of personality dimensions with the experience of suffering and caregiver burden, it is suggested that in order to reduce and moderate the pain and suffering of caregivers, educational and therapeutic programs to promote and improve positive personality abilities and adjust negative personality dimensions, including centers Counseling and treatment, hospitals and universities should be designed.