---

Abstract Aim and Background: Due to the high incidence of breast cancer and the importance of spiritual well-being (SWB) of patients with this type of cancer, this study was performed to predict the role of psychological, medical and demographic factors, on SWB in patients with breast cancer Methods and Materials: This Cross sectional study was a descriptive-analytic one conducted in 341 breast cancer patients with simple sampling methodology. Data collection instrument included a questionnaire contains 3 parts (demographic and medical information, SWB questionnaire and DASS-42 questionnaire). The data was analyzed by descriptive and analytical statistics (One way Analysis of Variance, Student t-Test, Pearson and Spearman correlation coefficients and Multiple linear regressions), with applying SPSSv20 software. Findings: Based on study findings, there was a statistically significant relationship between SWB and stress, anxiety and depression among breast cancer patients. The results of regression analysis indicated that the stress, anxiety and depression explained totally 39.5% of the variance of patients' SWB (R 2 = 39.5). Depression in the first was the best predictions of the breast cancer patients' SWB with R 2 = 26.2. Conclusions: According to the results obtained, SWB of patients with breast cancer is predicable according to the stress, anxiety and depression. Breast cancer patients with higher grades of SWB, had lower stress, anxiety and depression so SWB is a protective factor against stress, anxiety and depression.  

---

Aim and Background: One of the psychological factors that have complicated relationship with chronic diseases and physical problems is distress and frustration intolerance. The more a person tolerates stressful events, the less he has physical problems. Meanwhile, the mediating role of latent anger in the relationship between frustration intolerance and physical problems as a mechanism of this relationship has been neglected. The purpose of this study was to investigate the mediating role of latent anger in the relationship between frustration intolerance and physical problems.
Methods and Materials: The method of present study was non-experimental causal type. The statistical population included all men and women over 18 years of age in 1400. The sample size was 302 people who were selected from the statistical population by convenience sampling. Due to the outburst of Covid-19 disease, sampling was performed in cyberspace. The links to the online questionnaire containing the Failure Tolerance Questionnaire (Harrington, 2005), STAXI-2 State-Trait Anger Expression Inventory-2 (Spielberger, 1999) and the Physical Symptoms Scale (Hagiwara, 1992) were made available on Instagram, WhatsApp and Telegram virtual networks and the sample group was asked to answer the questions. Pearson correlation coefficient and path analysis method were used to investigate the research question. Data were analyzed using version 26 of Statistical Package for Social Sciences (SPSS-26) and Partial Least Squares-version 4 (Smart PLS 4).
Findings: The results showed that the indirect effects of frustration intolerance on muscular (β=-0.058, P<0.01), general (β=-0.076, P<0.01) and cardiovascular responses (β=-0.075, P<0.01) through latent anger were statistically significant.
Conclusions: The experience of failure beyond tolerance of individuals causes unpleasant emotions such as uncontrolled anger, which in turn causes physiological effects such as increased blood pressure and heart rate, which ultimately damage the cardiovascular system, muscles and general body responses.
Keywords: frustration intolerance, latent anger, physical problems.