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Showing 2 results for عرب عامری

حسن عبدی, عبداله قاسمی, الهه عرب عامری, فرشاد غزالیان,
Volume 15, Issue 2 (7-2017)
Abstract

Aim and Background: Deficiency in balance functions of individuals with attention deficit hyperactivity disorder (ADHD) have been highlighted in the body of literature. There is also a close relationship between physical activities and alleviation in behavioral disorders. The aim of this study was to investigate the effects of endurance training along with methylphenidate consumption on balance in rats with ADHD. Methods and Materials: The present study was a laboratory research. The samples were 35 Wistar rats (weight: 181.66 ± 8.69 g) which were randomly categorized into 5 groups (each group = 7 rats). To induce ADHD in the rats, they were injected 10 mg/kg of L-NAME for 8 weeks and 6 days per week based on the weight of the rats. The groups included 1 control group and 4 groups of ADHD (MPH consumption, endurance training, MPH consumption and endurance training, and ADHD). Open field, balance beam, and 5-band treadmill tests were used as research tools. Balance test was taken after 4 weeks of training. The medication group received 1 mg oral methylphenidate per kg weight of rats daily. The rats received training at a rate of 2 to 20 m/minute for 5 days a week for 28 days. The duration of the training in each session in the first week and the familiarization time was 2 meters/minute and overtime per week was 20 meters/minute. Data were analyzed using ANOVA. Findings: Analysis of data showed that there is no significant difference between the pretest and posttest in the control group (P = 0.17) and the ADHD group (P = 0.17). However, there was a significant difference between pretest and posttest in the ADHD + training, ADHD + methylphenidate, and ADHD + methylphenidate + exercise groups (P = 0.001). Furthermore, Tukey's post hoc test results showed that the control group's balance was better than all other groups (P < 0.001). The balance of all groups except the control group was better than ADHD group (P <0.001). There was no significant difference between ADHD + endurance exercises group and ADHD + methylphenidate group, and ADHD + methylphenidate and ADHD + endurance training + methylphenidate consumption groups in terms of balance (P < 0.001). Conclusions: It seems that it can be concluded that 30 minutes of endurance training per day can be a suitable alternative for methylphenidate among rats with ADHD.
Hassan Abdi , Abdollah Ghasemi , Elahe Arab-Ameri , Farshad Ghazalian ,
Volume 16, Issue 4 (5-2018)
Abstract

Aim and Background: Today different doses of drugs are used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Non-medical treatments such as physical activity have recently been considered. The purpose of this study was to investigate the effects of endurance training along with methylphenidate consumption on Behavioral symptoms in male rats with ADHD.

Methods and Materials: A laboratory research method was used. The subjects were 40 Wistar rats (mean and standard deviation of 181.78 ± 8.39 g) and aged 8-12 weeks. A 5-member group (mean and standard deviation of 182.6 ± 51.6 g) were randomly selected for sampling and blood sampling, and 35 rats (mean and standard deviation of 181.66 ± 8.09 g) to 5 Group 7 (control group and 4 groups of attention deficit hyperactivity disorder: methylphenidate use, endurance training, methylphenidate use and endurance training, without methylphenidate and no endurance training). 10 mg L-NAME for 8 weeks and 6 days per week for each rat was injected sub peritoneally for the attention deficit-hyperactivity disorder in rats. Angiotensin converting enzyme (ACE) and nitrite oxide (NO) were used to detect hypertension in rats after L-NAME injection. The open field test for over-active detection, and 5-band treadmill for endurance training of rats were used. The balance test was taken before and after 4 weeks of training. The drug group received 2 mg of methylphenidate daily per kg of body weight orally. The rats ran for 28 days each day (5 days a week) for 28 days. The practice load for training groups included running at speeds of 2 to 8 m / min for 30 minutes. Descriptive statistics were used to determine mean, mean, standard deviation, drawing tables and charts. For normalization of the distribution of dependent variables from the Kolmogorov-Smirnov and one-way variance for intra-group variation.

Findings: The results showed that the number of stands in the control group was higher than in all other groups and the number of traveled squares was less (p<0.001). The number of stands in the ADHD group was lower than in all other groups and the number of traveled squares was higher (p<0.001). There was no significant difference between the number of stands and the number of traveled squares in the ADHD group + Endurance exercises with ADHD + methylphenidate and also the ADHD group + methylphenidate + endurance training (p<0.001).

Conclusions: It seems that endurance training and methylphenidate consumption affect the behavioral patterns of the animal model of ADHD and it can be recommended that physical activity be used as an effective method to replace the use of methylphenidate.



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