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Normal 0 false false false MicrosoftInternetExplorer4 Introduction: Neuroleptic Malignant Syndrome (NMS) is an acute and dangerous syndrome which usually arise as a side-effect of Neuroleptic drugs. Its high mortality rate, acute course and the current controversies about the best treatment method indicates the necessity of further investigation on its clinical features, predisposing factors and effective therapeutic methods . Method and Materials: Retrospectively in a 4-year period, we studied patients hospitalized with NMS applying a 7-section questionnaire assessing: drug historys, the underlying psychiatric disorder, clinical signs and symptoms, laboratory findings, treatment methods and their outcomes, and duration of hospital stay. Findings: Rigidity and impaired consciousness were the most common clinical findings. Haloperidol, perphenazine and risperidone were the most common antisychotics used before the NMS onset. Mood disorders, schizophrenia, and mental retardation were the most frequent underlying disorders. The most common prescriptions for treatment of NMS were bromocriptine, fluid and electrolytes therapy, and amantadine . Discussion: In diagnosing the NMS, impaired consciousness, especially when being accompanied by rigidity and fever, may be a more sensitive criteria than it is currently believed. Bromocriptin and fluid and electrolyte replacement therapy among many other treatment methods, and also interventions for prevention of NMS complications may play important roles in reducing its mortality rate .  

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Aim and Background: The purpose of this study was to compare positive and negative psychological states between the two groups of patients with coronary heart disease with and without metabolic syndrome, and to investigate the relationship between these psychological factors and the risk of metabolic syndrome. Methods and Materials: In this comparative study, the study population consisted of all patients with middle-aged coronary artery disease (35-60 years old) who were enrolled at the Rehabilitation Center of the Cardiology Research Institute, Isfahan University of Medical Sciences, Iran, from 2012 to 2016. Totally, 61 patients were selected through purposive sampling in September, 2016. They participated in the research by completing some questionnaires including Hospital Anxiety and Depression Scale (HADS), Life Orientation Test-Revised (LOT-R), Oxford Happiness Questionnaire (OHQ), Adult Hope Scale (AHS), the Satisfaction with Life Scale (SWLS), and Positive and Negative Affect Scale (PANAS), and performing physiological assessments related to metabolic syndrome. Data were analyzed using analysis of variance (ANOVA), Mann-Whitney, and Pearson correlation tests. Findings: There were significant differences between the two groups of patients with coronary heart disease with and without metabolic syndrome in terms of depression, optimism, hope, and happiness. Moreover, depression, optimism, hope, and happiness had significant relationship with the risk of metabolic syndrome. Conclusions: The research findings support the link between psychological variables and metabolic syndrome.