Aim and Background: This meta-analysis evaluated the relationship between mental health and social support in Iran. Methods and Materials: In order to assess the relationship between mental health and social support, eight eligible studies with acceptable methodology were selected. Findings: The effect size of the relationship between mental health and social support in Iran was 0.369. Conclusions: Since the effect size of the relationship between mental health and social support in Iran was higher than moderate, social support needs to be strengthened in the country.