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Aim and Background: Given that, people&#039;s reaction to AIDS victims, desire to seek information about AIDS, and personal efforts to avoid exposure to AIDS could be affected by the level of anxiety a person experiences about AIDS. This paper assessed the reliability and validity of Persian version of multidimensional AIDS Anxiety Questionnaire&ndash; (MAAQ-P) in Iranian students . Methods and Materials: After face and content validity, to psychometry present tool, from 617 students of Qom non-medical universities, answered to response to (MAAQ-P). Samples selected by available method. In this study, we used confirmatory and explanatory factor analysis, Pearson correlation and Cronbach&#039;s Alpha in order to examine construct and concurrent validity, respectively. SPSS program version 18 and Lisrel version 8.8 were used to analyze the data in this study . Findings: The total (MAAQ-P) had a high internal consistency (Cronbach&rsquo;s alpha = 0.95). The Cronbach&rsquo;s alphas for the sub-scales were (physiological arousal, =&alpha;0. 78), (cognitive &shy;worry, =&alpha;0.78) (sexual inhibition, =&alpha;0.79), (discussion inhibition =&alpha;0.80) and (fear, =&alpha;0.80). Based on factor analysis, five dimensions Inventory 5.57 of the total variance explained, and they were approved. After one month test-retest study on a sub-sample of 40 students revealed Pearson correlation coefficient ranges from 0.65 to 0.96 was obtained (p<0.001). Conclusions: The results of the present study indicate that the Farsi version of MAAQ has a good reliability and validity and instruments that can be used to monitor societal changes in AIDS anxiety. &nbsp;