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Abstract Aim and Background: Due to the high incidence of breast cancer and the importance of spiritual well-being (SWB) of patients with this type of cancer, this study was performed to predict the role of psychological, medical and demographic factors, on SWB in patients with breast cancer Methods and Materials: This Cross sectional study was a descriptive-analytic one conducted in 341 breast cancer patients with simple sampling methodology. Data collection instrument included a questionnaire contains 3 parts (demographic and medical information, SWB questionnaire and DASS-42 questionnaire). The data was analyzed by descriptive and analytical statistics (One way Analysis of Variance, Student t-Test, Pearson and Spearman correlation coefficients and Multiple linear regressions), with applying SPSSv20 software. Findings: Based on study findings, there was a statistically significant relationship between SWB and stress, anxiety and depression among breast cancer patients. The results of regression analysis indicated that the stress, anxiety and depression explained totally 39.5% of the variance of patients' SWB (R 2 = 39.5). Depression in the first was the best predictions of the breast cancer patients' SWB with R 2 = 26.2. Conclusions: According to the results obtained, SWB of patients with breast cancer is predicable according to the stress, anxiety and depression. Breast cancer patients with higher grades of SWB, had lower stress, anxiety and depression so SWB is a protective factor against stress, anxiety and depression.  

Keywords: Breast Cancer, Demographic Factors, Medical Factors, Psychological Factors, Spiritual Well-being&, nbsp, &, nbsp

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