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Abstract &nbsp; Aim and Background: The purpose of the present study was to examination of the religious orientation and burden of family as predictors of treatment permanence of addiction. Methods and Materials: This descriptive, analytic cross sectional study was conducted on one hundred Self-introduced Addicts who reoffered to Isfahan centers of addiction treatment during 2012-2013 were selected using simple sampling. The clinical and demographic characteristics information, George&acute;s religious orientation of addict questionnaire and Zarit Burden questionnaire. All analyses were performed with descriptive and analytic statistical (multiples regression and Pearson coefficients correlation) methods in SPSS for Windows 18.0 (SPSS Inc., Chicago, IL, USA). Findings: Based on study findings there was a statistically significant relationship between the religious orientation and burden of family with treatment permanence of addiction (p<0.001). Hence, burden of family is a negative predictor of permanence of addiction and predicts 10 percent of permanence of addiction variance. Also religious orientation is a positive predictor of permanence of addiction and predicts 20 percent of permanence of addiction variance. Conclusion: Since religious orientation and spirituality being surrounded on all affairs of life, has an important role in inhibition of the tendency of the drug, it&rsquo;s suggested to focus on religious history and spiritual aspect thought medical cure process.

Keywords: Addict, Burden of Family, Religious Orientation, Self-introduced Addicts, Treatment Permanence

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