Head trauma and brain injury are common causes of emergency cases, and predispose multiple psychiatric complications. The head trauma, itself, often occurs after some psychiatric disorders, like mood or substance related disorders. So, the complex interaction of these factors often causes difficulties in diagnosis and management of the patients. The side effects of surgical and medical treatments may also entangles these processes. Here we presents the history of a young adult patient with this collection of factors, i.e.: head trauma, delirium, and substance use. Then we discuss about the differential diagnosis and management.

Keywords: Trauma, Delirium, Mania, Substance

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