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Aim and Background: The present study examined the predictability of quality of life (QOL) based on personality traits and demographic characteristics of drug addicts. Methods and Materials: In the current descriptive, cross-sectional study, 200 individuals were randomly selected from addicts who referred to drug addiction treatment centers in Tehran (Iran). The World Health Organization Quality of Life Scale-Brief Version (WHOQOL-BREF) and the short version of Cloninger's Temperament and Character Inventory (TCI) were completed by the participants. The collected data was analyzed using Pearson's correlation coefficient and stepwise regression analysis. Findings: Personality traits of self-directedness, persistence, and employment status explained 33% of variance of the total QOL score. Self-directedness and persistence explained 16% of the variance of physical subscale of QOL. Self-directedness, reward dependence, and employment status explained 34% of the variance of psychological subscale of QOL. Self-directedness and employment status explained 20% and 26% of the variance of social and environmental subscales of QOL, respectively. The mentioned factors could significantly predict QOL. Conclusions: Improving self-directedness and reward dependence along with decreasing persistence and unemployment would reduce QOL in drug addicts.

Keywords: Quality of life, Personality traits, Addicts.

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