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Background &Aime: Consider to importance of happiness in life, the research was accomplished to qualify role of gender, native, religiosity and family function in prediction of students&#039; happiness of Tabriz Medical Science University. Material and Methods: This research was correlation-descriptive study. The statistical population included all students of Tabriz Medical Science University who were studying in the spring semester of 2009; 372 students were chosen by the multi-stage cluster random sampling method and they accomplished Family Assessment Device (FAD), Memorial University of Newfoundland Scale of Happiness (MUNSH) and Religiosity Through Reliance On Islam Assessment Scale (RRIAS). Their age, gender and native were asked. Pearson Correlation Coefficient and Stepwise Multiple Regression statistical methods were used for analyzing data. Results: There are significant correlation between family function and also, religiosity through reliance on Islam with happiness (P<0.01); factors of gender, roles, native, religiosity and relationship predict 32 % variance of happiness (P<0.01). Predictor variables Beta coefficients show that gender is most important predictor for happiness. Conclusion: students who live with their family are happier than who don&rsquo;t live and similarly males are happier than females. Students who have adaptive family function, tendency and commitment to Islam are happier. So, apply of family instruction workshop and effective religious programs are suggested increasing happiness of students. Key Words: Religiosity through Reliance on Islam- Family Function- Happiness &ndash;Demographic Factors - student

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