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Introduction: The aim of this survey was to assess psychometric properties of GHQ-28 in Iranian psychiatric population and appropriating it as a screening instrument for assessing general health in this population. Method and Materials: This was a psychometric study executed on 80 psychiatric patients and 80 matched normal participants. The assessments consisted of a psychiatrist’s interview based on DSM.IV criteria, and administration of GHQ-28 and a demographic questionnaire. Data was analyzed using factor, discrimination and regression analysis methods, as well as Pearson’s correlation co-efficient, Spearman- Brown’s and Guttmann’s split tests.  Findings: Four factors were extracted from the GHQ-28, of which the first three explained the most percenttage of variance. Clinical cut-off point, sensitivity, specificity and classification error were found to be 24, 0.80, 0.99, 0.10 respectively. Criterion validity Chronbach's alpha and split reliability co-efficient were found to be 0.78, 0.97 and 0.90 respectively.  Discussion: Factor analysis revealed that the four factors which are the basics in this questionnaire have a high internal consistency. The calculated optimal clinical cut-off point for screening general health in Iranian population was 24 which ensure optimal psychometric indices. Coefficients of criterion validity, structural validity and reliability showed that GHQ-28 is one of the most valid instruments for screening general health. 

Keywords: GHQ-28, Factor structure, Cut&, ndash, off point, Psychometric properties, General health.

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